TCS-1205
-2-(5-nitro-1H-indol-3-yl)-2-oxo-N-(1-phenylethyl)acetamide.png)
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| Names | |
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| IUPAC name
2-(5-nitro-1H-indol-3-yl)-2-oxo-N-[(1R)-1-phenylethyl]acetamide
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| Identifiers | |
3D model (JSmol)
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| ChEMBL | |
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PubChem CID
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| Properties | |
| C18H15N3O4 | |
| Molar mass | 337.335 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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TCS 1205 is an organic chemical compound. It is a benzodiazepine site agonist selective for certain sub-units.
Pharmacology
[edit]TCS 1205 acts at the benzodiazepine binding site, it is selective for the a1 and a2 subunits of the GABAA receptor.[1] In vivo, it has anxiolytic effects but no sedative effects.[2][3]
Chemistry
[edit]Despite acting at the benzodiazepine receptor, it does not contain the benzodiazepine structure, it could therefore be classed as a Nonbenzodiazepine.
References
[edit]- ^ "TCS 1205" (PDF). Certificate of Analysis. Tocris Bioscience.
- ^ "TCS 1205". AbMole BioScience.
- ^ Taliani S, Cosimelli B, Da Settimo F, Marini AM, La Motta C, Simorini F, et al. (June 2009). "Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor". Journal of Medicinal Chemistry. 52 (12): 3723–3734. doi:10.1021/jm9001154. PMID 19469479.
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