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Membrane-type matrix metalloproteinase-1

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Membrane-type matrix metalloproteinase-1
Identifiers
EC no.3.4.24.80
CAS no.161384-17-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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Membrane-type matrix metalloproteinase-1 (EC 3.4.24.80, matrix metalloproteinase 14) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37-Leu. Other bonds hydrolysed include Gly35-Ile in the propeptide of collagenase 3, and Asn341-Phe, Asp441-Leu and Gln354-Thr in the aggrecan interglobular domain

This enzyme belongs to peptidase family M10.

See also

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References

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  1. ^ Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M (September 2001). "Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion". The EMBO Journal. 20 (17): 4782–93. doi:10.1093/emboj/20.17.4782. PMC 125610. PMID 11532942.
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