Bialik was previously set to host the final week of episodes before the show's summer hiatus.
The series was based on Miranda Hart's BBC comedy Miranda.
"It’s been hard and we’re grateful to have gotten the opportunity to work with him," Bialik added.
Contestant Dan Oxman got his flirt on with the game show host.
"He creates community for people, lets them know that there's somebody here for you..."
The 30-second tribute featured a montage of Leslie Jordan in a variety of Fox shows.
"There will never be anyone like him."
"It is very, very funny."
FOX renewed 9-1-1: Lone Star, but is still undecided on two of its hit dramas, 9-1-1 and The Resident.
For every successful remake (see: The Office), there are a dozen failures.
You can't have a cat comedy and give a major episodic role to a DOG.
Bialik stars with Swoosie Kurtz, Leslie Jordan and Cheyenne Jackson in this adaptation of the British sitcom Miranda.
Fox's winter TV schedule is finally here.