Chemical tools articles within Nature

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  • Article |

    Targeted protein relocalization using shuttle proteins with potent ligands amenable to incorporation into targeted relocalization activating molecules could be used to regulate cellular physiology and correct disease states in neurodegenerative diseases, cancer and genetic disorders.

    • Christine S. C. Ng
    • , Aofei Liu
    •  & Steven M. Banik

  • Article |

    Global profiling of hyper-reactive tryptophan sites across whole proteomes using tryptophan chemical ligation by cyclization (Trp-CLiC) reveals a systematic map of tryptophan residues that participate in cation–π interactions, including functional sites that can regulate protein-mediated phase-separation processes.

    • Xiao Xie
    • , Patrick J. Moon
    •  & Christopher J. Chang

  • Article
    | Open Access

    Studies using genetic screening, biophysical characterization and structural reconstitution elucidate the mechanism of action and enable rational design of a new class of functional compounds that glue target proteins to E3 ligases via intramolecularly bridging two domains to enhance intrinsic protein–protein interactions and promote target ubiquitination and degradation.

    • Oliver Hsia
    • , Matthias Hinterndorfer
    •  & Alessio Ciulli

  • Article |

    Lysosome-targeting chimaeras—in which a small molecule or antibody is connected to a glycopeptide ligand to form a conjugate that can bind a cell-surface lysosome-shuttling receptor and a protein target—are used to achieve the targeted degradation of extracellular and membrane proteins.

    • Steven M. Banik
    • , Kayvon Pedram
    •  & Carolyn R. Bertozzi

  • Letter |

    Microbial generation of a terminal-alkyne-containing amino acid can be encoded into E. coli and provides the potential for in vivo generation of proteins and natural products for click chemistry.

    • J. A. Marchand
    • , M. E. Neugebauer
    •  & M. C. Y. Chang

  • Letter |

    Small molecules are powerful tools for investigating protein function, and can serve as leads for new therapeutics, but most human proteins lack known small-molecule ligands; here, a quantitative analysis of cysteine-reactive small-molecule fragments screened against thousands of proteins is reported.

    • Keriann M. Backus
    • , Bruno E. Correia
    •  & Benjamin F. Cravatt

  • Outlook |

    In a pioneering move, the compound JQ1 was released to the community for free. The impact that this has had on research and development is slowly coming into focus.

    • Andrew R. Scott

  • News |

    A chemical that stains Alzheimer's-associated proteins may help cells to cope with toxic trash.

    • Ewen Callaway

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