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The surgical gloves are off in the trailer ABC just dropped for Season 21 of Grey’s Anatomy. Not only does it appear that Catherine is suing Meredith over ownership of her groundbreaking Alzheimer’s research, but the boss lashes out at Bailey for standing with the interns in defense of Lucas. “You think you’re God’s gift to this hospital?” Catherine scoffs. “You’re just another doctor.”

“Talk to the hand,” Miranda replies — not in words, though, with a slap!

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Elsewhere in the extended promo, Richard and Winston have their hands full with a bungee jumper whose cord snapped. Jules and Mika face the awkward aftermath of their near kiss. After years and years away, Kali Rocha’s Dr. Sydney Heron is back to “heal with love.” And Jo — as she as well as we knew that she’d have to eventually — tries to broach the subject of her surprise pregnancy with significant other Link. (Forgot that she really is expecting? Our Season 20 finale recap can fill in the blanks.)

As you may have read, when Grey’s Anatomy returns on Thursday, Sept. 26, there will be changes left, right and center. For starters, the long-running drama has a new time slot — 10/9c. On top of that, Jason George, who spent the last seven seasons fighting fires as Ben on much-missed spinoff Station 19, will be bringing back Bailey’s husband to complete his medical residency. Jake Borelli (Levi) and Midori Francis (Mika) are on their way out, and on his way in is Zoey’s Extraordinary Playlist alum Michael Thomas Grant as James, Grey Sloan’s new chaplain.

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Grey’s Anatomy Season 21: Everything We Know So Far