Methapyrilene: Difference between revisions

{{Short description|Chemical compound}}

{{hatnote|"Thionylan" redirects here. Not to be confused with thionyl halides: [[thionyl fluoride]], [[thionyl chloride]] and [[thionyl bromide]].}}

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'''Methapyrilene''' is an [[antihistamine]] and [[anticholinergic]] of the [[pyridine]] [[chemical class]] which was developed in the early 1950s. It was sold under the trade names Co-Pyronil and Histadyl EC in the UK.<ref>{{cite news |date=July 1979 |title=Archive. |url=http://www.thefreelibrary.com/Archive.-a0119048413 |work=[[Birmingham Post]] |via=[[The Free Library]]}}</ref> It has relatively strong [[sedative]] effects, to the extent that its primary use was as a medication for [[insomnia]] rather than for its antihistamine action. Together with [[Hyoscine hydrobromide|scopolamine]], it was the main ingredient in [[Sominex]], Nytol, and Sleep-Eze. It also provided the sedative component of Excedrin PM.<ref>{{cite news |date=1978-06-13 |title=FDA Seeks Restrictions On Sleeping Aid Drugs |url=https://newspapers.com/image/233886246/ |url-access=subscription |work=[[Daily Press (Virginia)|Daily Press]] |via=[[Newspapers.com]] |volume=83 |issue=164 |page=1}}</ref> All of these products were reformulated in the late 1970s<ref>{{cite news | vauthors = Cook C |date=1979-06-28 |title=Sleep aids back with new drug {{!}} Critics assail 'human testing' |url=https://www.newspapers.com/image/191023340/ |url-access=subscription |work=[[Star Tribune|The Minneapolis Star]] |via=[[Newspapers.com]] |pages=[https://www.newspapers.com/newspage/191023340/ 1A], [https://www.newspapers.com/newspage/191023631/ 6A]}}</ref> when methapyrilene was demonstrated to cause [[liver cancer]] in rats when given chronically.<ref>{{cite journal | vauthors = Lijinsky W, Reuber MD, Blackwell BN | title = Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride | journal = [[Science (journal)|Science]] | volume = 209 | issue = 4458 | pages = 817–819 | date = August 1980 | pmid = 7403848 | doi = 10.1126/science.7403848 | bibcode = 1980Sci...209..817L }}</ref>

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*[[Methaphenilene]]

{{Reflist}}

{{Antihistamines}}

[[Category:]]

[[Category:]]

[[Category:Dimethylamino compounds]]