Phenylacetone: Difference between revisions
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'''Phenylacetone''', sometimes abbreviated '''P2P''' is an [[organic compound]]. It is a clear oil with a [[refractive index]] of 1.5168. This chemical is used in the manufacture of [[methamphetamine]] and [[amphetamine]]. Due to the illicit uses in [[clandestine chemistry]], it was made a [[controlled substance]] in 1979 in the [[United States]]. This substance has a very strong and persistent odor that is difficult to remove from walls, carpets, clothing, or skin. The persistence of the smell may have played a role in the decline of popularity of phenylacetone in methamphetamine synthesis and consequently in the DEA demoting phenylacetone from List I to List II.<ref>{{cite book | editor = Frederick Smith, Jay Siegel |title= [[Handbook of Forensic Drug Analysis]] |year= 2005 |publisher= Elsevier Academic Press |location= Burlington, Massachusetts |isbn= 0-12-650641-8 |pages= 499 | url = http://books.google.com/books?id=8JsQgRO3QcwC&pg=PA499 | format = [[Google Books]] excerpt | chapter= 8 – Illicit drug manufacture (with an emphasis on clandestine methamphetamine production): Synthetic methods and law enforcement concerns | author = Robert B. Palmer}}</ref> |
'''Phenylacetone''', sometimes abbreviated '''P2P''' is an [[organic compound]]. It is a clear oil with a [[refractive index]] of 1.5168. This chemical is used in the manufacture of [[methamphetamine]] and [[amphetamine]]. Due to the illicit uses in [[clandestine chemistry]], it was made a [[controlled substance]] in 1979 in the [[United States]]. This substance has a very strong and persistent odor that is difficult to remove from walls, carpets, clothing, or skin. The persistence of the smell may have played a role in the decline of popularity of phenylacetone in methamphetamine synthesis and consequently in the DEA demoting phenylacetone from List I to List II.<ref>{{cite book | editor = Frederick Smith, Jay Siegel |title= [[Handbook of Forensic Drug Analysis]] |year= 2005 |publisher= Elsevier Academic Press |location= Burlington, Massachusetts |isbn= 0-12-650641-8 |pages= 499 | url = http://books.google.com/books?id=8JsQgRO3QcwC&pg=PA499 | format = [[Google Books]] excerpt | chapter= 8 – Illicit drug manufacture (with an emphasis on clandestine methamphetamine production): Synthetic methods and law enforcement concerns | author = Robert B. Palmer}}</ref> |
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The prime reason for the decline in interest in phenylacetone is the chemist's preference for more immediate precursors available over-the-counter, such as ephedrine. |
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== Preparation == |
== Preparation == |
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Revision as of 22:25, 16 March 2009
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| Names | |
|---|---|
| IUPAC name
1-phenylpropan-2-one
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| Other names
benzyl methyl ketone; methyl benzyl ketone; phenyl-2-propanone
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| Identifiers | |
| ECHA InfoCard | 100.002.859 |
CompTox Dashboard (EPA)
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| Properties | |
| Density | 1.006 g/mL |
| Melting point | −15 °C |
| Boiling point | 214 — 216 °C |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Phenylacetone, sometimes abbreviated P2P is an organic compound. It is a clear oil with a refractive index of 1.5168. This chemical is used in the manufacture of methamphetamine and amphetamine. Due to the illicit uses in clandestine chemistry, it was made a controlled substance in 1979 in the United States. This substance has a very strong and persistent odor that is difficult to remove from walls, carpets, clothing, or skin. The persistence of the smell may have played a role in the decline of popularity of phenylacetone in methamphetamine synthesis and consequently in the DEA demoting phenylacetone from List I to List II.[1]
Preparation
There are many methods in the scientific literature to prepare phenylacetone, and due to its controlled nature there is crossover into popular literature such as works by Uncle Fester and Alexander Shulgin. Not surprisingly there is also a fair amount of data available on the Internet relating to the preparation of phenylacetone.
A conceptually simple, although low-yielding, example of phenylacetone organic synthesis is the Friedel-Crafts alkylation of benzene with chloroacetone. The reaction is low yielding because the monoalkylation product is activated towards additional substitution at the ortho and para positions.
Phenylacetone synthesis via the Friedel-Crafts alkylation of Benzene with chloroacetone.
Phenylacetone can also be produced from many other chemicals. For example, phenylacetic acid is distilled with lead acetate to yield phenylacetone. Another is, benzaldehyde is reacted with nitroethane yielding phenyl-2-nitropropene, which is reduced, usually in the presence of acid, to phenylacetone.
References
- ^ Robert B. Palmer (2005). "8 – Illicit drug manufacture (with an emphasis on clandestine methamphetamine production): Synthetic methods and law enforcement concerns". In Frederick Smith, Jay Siegel (ed.). [[Handbook of Forensic Drug Analysis]] (Google Books excerpt). Burlington, Massachusetts: Elsevier Academic Press. p. 499. ISBN 0-12-650641-8.
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