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== The B-cell receptor in malignancy ==
The B-cell receptor has been shown to be involved in the pathogenesis of various B cell-derived lymphoid cancers.<ref name="pmid23597135"/> Although it may be possible that stimulation by antigen binding contributes to the proliferation of malignant B cells,<ref>{{cite journal|last=Daneshek|first=W|author2= RS Schwartz|title=Leukemia and auto-immunization- some possible relationships|journal=Blood|year=1959|volume=14}}</ref> increasing evidence implicates antigen-independent self-association of BCRs as a key feature in a growing number of B-cell neoplasias.<ref>{{cite journal|last=Corcos|first=D|title=Oncogenic potential of the B-cell antigen receptor and its relevance to heavy chain diseases and other B-cell neoplasias: a new model|journal=Res Immunol.|year=1990|volume=141|issue=6|doi=10.1016/0923-2494(90)90022-Q|pages=543–53|pmid=2284498}}</ref><ref name="pmid8548286">{{cite journal |author=Corcos D|title=Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein|journal=Curr. Biol.|volume=5 |issue=10 |pages=1140–8 |year=1995 |pmid=8548286 |doi=10.1016/S0960-9822(95)00230-2 |author-separator=, |author2=Dunda O |author3=Butor C |display-authors=3 |last4=Cesbron |first4=Jean-Yves |last5=Lorès |first5=Patrick |last6=Bucchini |first6=Danielle |last7=Jami |first7=Jacques}}</ref><ref>{{cite journal |title=Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma |journal=Nature |volume=463 |issue=7277 |pages=88–92 |year=2010 |bibcode=2010Natur.463...88D |doi=10.1038/nature08638 |pmid=20054396 |last1=Davis |first1=RE |last2=Ngo |first2=Vu N.|last3=Lenz |first3=G |last4=Tolar |first4=P |last5=Young |first5=RM |last6=Romesser |first6=PB |last7=Kohlhammer |first7=H |last8=Lamy |first8=L |last9=Zhao |first9=H |last10=Yang |first10=Y |last11=Xu |first11=W |last12=Shaffer |first12=AL |last13=Wright |first13=G |last14=Xiao |first14=W |last15=Powell |first15=J |last16=Jiang |first16=JK |last17=Thomas |first17=CJ |last18=Rosenwald |first18=A |last19=Ott |first19=G |last20=Muller-Hermelink |first20=HK |last21=Gascoyne |first21=RD |last22=Connors |first22=JM |last23=Johnson |first23=NA |last24=Rimsza |first24=LM |last25=Campo |first25=E |last26=Jaffe |first26=ES |last27=Wilson |first27=WH |last28=Delabie |first28=J |last29=Smeland |first29=EB |last30=Fisher |first30=RI |last31=Braziel |first31=RM |last32=Tubbs |first32=RR |last33=Cook |first33=JR |last34=Weisenburger |first34=DD |last35=Chan |first35=WC |last36=Pierce |first36=SK |last37=Staudt |first37=LM |displayauthors=37 |pmc=2845535}}</ref><ref>{{cite journal |author1=Dühren-von Minden M |author2=Übelhart R |author3=Schneider D |author4=Wossning T |author5=Bach MP |author6=Buchner M |author7=Hofmann D |author8=Surova E |author9=Follo M |author10=Köhler F |author11=Wardemann H |author12=Zirlik K |author13=Veelken H |author14=Jumaa H |displayauthors=37 |title=Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling |journal=Nature |volume=489 |pages=309–312 |year=2012 |bibcode= 2012Natur.489..309M |doi= 10.1038/nature11309 |pmid= 22885698 |issue=7415 }}</ref> B-cell receptor signalling is currently a therapeutic target in various lymphoid neoplasms.
==References==
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