USC makes its Big Ten debut Saturday with a marquee matchup against Michigan in the Big House (3:30 p.m. ET, CBS). It's the first matchup between the two programs since 2007 and the 11th overall, including eight meetings in the Rose Bowl. The Trojans have never won in Ann Arbor. USCFootball.com's Chris Trevino and Sam Webb of The Michigan Insider analyzed key players and matchups and offered their predictions ahead of the action.
The game marks the first career start for Wolverines quarterback Alex Orji. The junior signal-caller has completed just four passes in his collegiate career. The Trojans boast a Heisman Trophy contender in Miller Moss on the other side. He's completed 72.7% of his passes for 607 yards and two touchdowns with no interceptions through two games.
USC is coming off a bye week and enters the matchup as a 5.5-point favorite after starting the season 2-0. Michigan rebounded from a blowout loss to Texas in Week 2 with a 28-18 win over Arkansas State last weekend.
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Below is insider analysis from both sides of the USC-Michigan matchup in Week 4: