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Martin Parniske

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Parniske, Martin
NationalityGerman
Awards2013 European Research Council Advanced Grant
Scientific career
FieldsGenetics, Plant Molecular Biology, Microbiology, Biotic interactions of plants
InstitutionsLudwig-Maximilians University Munich

Martin Parniske (birthdate and place) is a German biologist with a specialisation in genetics, microbiology and biochemistry. He is university professor and the head of the Institute of Genetics at the Faculty of Biology of the Ludwig Maximilian University of Munich.[1] Parniske's scientific focus is on the molecular interaction between plants and symbiotic and pathogenic microorganisms including bacteria, fungi and oomycetes.

Biography

Parniske studied biology, microbiology, biochemistry and genetics at the universities of Konstanz and Marburg, Germany. From 1986 until 1991 he performed diploma and doctoral studies in the laboratory of Dietrich Werner on chemical communication of the root with the bacterial microbiome with a focus on flavonoids and isoflavonoids. From 1992 until 1994 Parniske carried out biochemical studies on the interaction of plant transcription factors and DNA at the Institute of Biochemistry of the Max Planck Institute for Plant Breeding Research in Cologne, Germany as a postdoctoral fellow funded by the German Research Foundation. From 1994 until 1998 he studied the evolution of plant disease resistance genes in the lab of Jonathan D.G. Jones. In 1998 Parniske was appointed as an independent group leader at the Sainsbury Laboratory in Norwich, UK. In 2004 he accepted a call for the chair of Genetics at the Faculty of Biology of the Ludwig Maximilian University of Munich, Germany.[1] From 2011 until 2013 he acted as the Dean of the Faculty of Biology of the LMU Munich. As the head of the Institute of Genetics at the Faculty of Biology of the LMU Munich, Parniske teaches students at the Bachelor, Master and Doctoral (Dr. rer. nat.) level. Topics taught include Genetics, Molecular Plant-Microbe Interactions, Genetics and Society, Plant Nutrition and Sustainable Food Production.

Scientific contribution

Evolution of plant disease resistance genes

Parniske joined the laboratory of the plant geneticist Jonathan D.G. Jones at the Sainsbury Laboratory in Norwich, United Kingdom in November 1994. He addressed the fundamental question in plant disease resistance research, how plants can keep pace with the evolutionary speed of microbial pathogens that have a much shorter generation time than their host plants and thus evade recognition by plant receptors through diversifying selection. Parniske discovered that recombination within and between resistance gene clusters is a key to the evolution of novel recognition specificities of pathogenic microbes by plants.[2][3]

Chemical communication between bacteria and plant roots

During his doctoral work Parniske observed that incompatible bradyrhizobium/genotypes of soybean rhizobia can lead to the induction of defense responses inside root nodules including the accumulation of phytoalexins, plant toxins produced upon biotic stress.[4] Parniske discovered that the soybean phytoalexin glyceollin is toxic for soybean rhizobia and that low concentrations of isoflavonoids secreted by soybean roots induce a resistance against this antibiotic plant compound.[5]

Genetics of plant root endosymbiosis

Parniske identified a set of plant mutants defective in plant root symbioses with both arbuscular mycorrhiza fungi and nitrogen-fixing rhizobia bacteria.[6] These mutants enforced the idea that plant root endosymbioses with bacteria and fungi share a common genetic basis. Because arbuscular mycorrhiza dates back to the first land plant and the root nodule symbiosis is much younger, this common gene set revealed that the nitrogen-fixing root nodule symbiosis evolved by co-opting genes from the existing arbuscular mycorrhiza symbiosis. By map-based cloning of so-called “common symbiosis genes”, the Parniske lab contributed to the identification of several components directly or indirectly involved in a plant signal transduction process required for both symbioses. These include a receptor-like kinase,[7] nucleoporins,[8][9] potassium channels required for nuclear calcium oscillations[10] and a nuclear localized complex comprising a calcium-and-calmodulin dependent protein kinase[11] and its phosphorylation target CYCLOPS, a DNA-binding transcriptional activator.[12]Cite error: The <ref> tag name cannot be a simple integer (see the help page). The discovery of these genes and the postulated signal transduction processes had a major impact on this research field. The Parniske lab discovered that CYCLOPS is an interactor and phosphorylation substrate of the calcium- and calmodulin-dependent protein kinase CCaMK. Moreover, the role of CYCLOPS, initially annotated as a protein with unknown function, was identified as a DNA-binding transcriptional activator.Cite error: The <ref> tag name cannot be a simple integer (see the help page). Research in the Parniske lab clarified the role of the CCaMK/CYCLOPS complex as a major regulatory hub in symbiotic signal transduction.

Awards

Parniske was Thomson Reuters Highly Cited Researcher in 2014 und 2015. In 2013 he received the European Research Council Advanced Grant for research on the “Evolution of the molecular mechanisms underlying the nitrogen-fixing root nodule symbiosis”.[13] His postdoctoral research was funded by the EMBO and the Marie Curie Fellows Association. In 2014 Parniske received the Thomson Reuters Highly Cited Researcher award in recognition of ranking among the top 1% of researchers for most cited documents in the field of animal and plant sciences.[14]

Publications

Category

Category:ISI highly cited researchers (Wird erst bei Veröffentlichung des Artikels in die entsprechende Kategorie verlinkt.)

References

  1. ^ a b "Prof. Martin Parniske". LMU Munich, Faculty of Biology, Genetics. Retrieved 2017-02-07.
  2. ^ Parniske M, Hammond-Kosack KE, Golstein C, Thomas CM, Jones DA, Harrison K, Wulff BB, and Jones JD. “Novel Disease Resistance Specificities Result from Sequence Exchange between Tandemly Repeated Genes at the Cf-4/9 Locus of Tomato.” Cell 91, no. 6 (December 12, 1997): 821–32. doi:10.1016/S0092-8674(00)80470-5.
  3. ^ Parniske M, Jones JD. Recombination between diverged clusters of the tomato Cf-9 plant disease resistance gene family. Proceedings of the National Academy of Sciences of the United States of America Volume: 96 Issue: 10 Pages: 5850-5855 Published: MAY 11 1999. doi:10.1073/pnas.96.10.5850
  4. ^ Parniske M, Zimmermann C, Cregan PB, and Werner D. “Hypersensitive Reaction of Nodule Cells in the Glycine Sp./Bradyrhizobium japonicum‐Symbiosis Occurs at the Genotype‐Specific Level*.” Botanica Acta 103, no. 2 (May 1, 1990): 143–48. doi:10.1111/j.1438-8677.1990.tb00140.x
  5. ^ Parniske M, Ahlborn B, Werner D. Isoflavonoid-inducible resistance to the phytoalexin glyceollin in soybean rhizobia. Journal of Bacteriology Volume: 173 Issue: 11. 3432-3439. Jun 1991. doi:10.1128/jb.173.11.3432-3439.1991
  6. ^ Wegel E, Schauser L, Sandal N, Stougaard J, and Parniske M. 1998. Mycorrhiza Mutants of Lotus japonicus Define Genetically Independent Steps During Symbiotic Infection. Molecular Plant Microbe Interactions 11: 933–936. link: http://apsjournals.apsnet.org/doi/abs/10.1094/MPMI.1998.11.9.933
  7. ^ Stracke S, Catherine K, Satoko Y, Lonneke M, Shusei S, Takakazu K, Satoshi T, Sandal N, Stougaard J, Szczyglowski K, and Parniske M. A plant receptor-like kinase required for both bacterial and fungal symbiosis. Nature 417, no. 6892 (June 27, 2002): 959–62. doi:10.1038/nature00841.
  8. ^ Saito K, Yoshikawa M, Yano K, Miwa H, Uchida H, Asamizu E, Sato S, Tabata S, Imaizumi-Anraku H, Umehara Y, Kouchi H, Murooka Y, Szczyglowski K, Downie A, Parniske M, Hayashi M, and Kawaguchia M. NUCLEOPORIN85 is Required for Calcium Spiking, Fungal and Bacterial Symbioses, and Seed Production in Lotus japonicus. Plant Cell Volume: 19 Issue: 2 Pages: 610-624 Published: Feb 2007. doi:10.1105/tpc.106.046938
  9. ^ Groth M, Naoya T, Jillian P, Uchida H, Dräxl S, Brachmann A, Sato S, Tabata S, Kawaguchi M, Wang TL and Parniske M. NENA, a Lotus japonicus Homolog of Sec13, Is Required for Rhizodermal Infection by Arbuscular Mycorrhiza Fungi and Rhizobia but Dispensable for Cortical Endosymbiotic Development. Plant Cell Volume: 22 Issue: 7 Pages: 2509-2526 Published: Jul 2010. doi:10.1105/tpc.109.069807
  10. ^ Charpentier M, Bredemeier R, Wanner G, Takeda N, Schleiff E, and Parniske M. (2008). Lotus japonicus CASTOR and POLLUX Are Ion Channels Essential for Perinuclear Calcium Spiking in Legume Root Endosymbiosis. Plant Cell 20, 3467-3479. doi:10.1105/tpc.108.063255
  11. ^ Tirichine L, Imaizumi-Anraku H, Yoshida S, Murakami Y, Madsen LH, Miwa H, Nakagawa T, Sandal N, Albrektsen AS, Kawaguchi M, Downie A, Sato S, Tabata S, Kouchi H, Parniske M, Kawasaki S, and Stougaard J. Deregulation of a Ca2+/calmodulin-dependent kinase leads to spontaneous nodule development. Nature Volume: 441 Issue: 7097 Pages: 1153-1156 Published: Jun 28 2006. doi:10.1038/nature04862
  12. ^ Yano K, Yoshida S, Müller J, Singh S, Banba M, Vickers K, Markmann K, White C, Schuller B, Sato S, Asamizu E, Tabata S, Murooka Y, Jillian P, Wang TL, Kawaguchi M, Imaizumi-Anraku H, Hayashi M, Parniske M. “CYCLOPS, a mediator of symbiotic intracellular accommodation.” Proceedings of the National Academy of Sciences 105, no. 51 (December 23, 2008): 20540–45. doi:10.1073/pnas.0806858105.
  13. ^ "Molecular inventions underlying the evolution of the nitrogen-fixing root nodule symbiosis". European Research Council. Retrieved 2017-02-05.
  14. ^ The world's most influential scientific minds 2014, S.90
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